The size of global hollow fiber filtration market in terms of revenue was estimated to be worth $303 million in 2021 and is poised to reach $597 million by 2026, growing at a CAGR of 14.5% from 2021 to 2026. 

The growth of the global market is driven by factors such as the rising preference for continuous manufacturing, the increasing use of single-use technologies, and the rising biopharmaceutical industry. In addition, emerging economies and increased investment in cell-based research are expected to provide significant growth opportunities for players in the market.

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Hollow Fiber Filtration Market Dynamics

Driver: Growth in the biopharmaceutical industry

Many companies are investing heavily in the development of biologics and biosimilars. More than half of the drug candidates in the discovery stage are biologics, such as proteins, peptides, and monoclonal antibodies. Biologics are expected to contribute around half of the revenue generated by the top 100 pharmaceutical products in the coming years.

In 2019, the US FDA approved 48 new drugs and biologics. Growing investments by biopharmaceutical companies to develop biologics and biosimilars are further expected to increase the number of approved products worldwide and increase the manufacturing of biopharmaceutical drugs. Although small-molecule drugs dominate the global pharmaceutical market, the share of biologics, biosimilars, and large-molecule drugs is growing due to the launch of new biologics-based drugs and increased revenues from existing biologics. In the bioprocessing industry, filtration is an essential step as a standard unit operation or with other unit operations for separation, isolation, and purification of the biotherapeutics. It is also extremely important for recombinant proteins, vaccines, gene therapy, and cell therapy products. To cater to the rising demand for biopharmaceuticals, companies are focusing on implementing advanced bioprocessing systems throughout the process, including filtration systems such as perfusion systems that utilize hollow fiber filters. The demand for these systems is increasing among biopharmaceutical companies as these systems help decrease the costs associated with complicated steps, increase productivity, and help in adherence to GMP and FDA guidelines for filtration.

Thus, the growth in the biopharmaceutical industry is expected to boost the growth of the market.

Opportunity: Emerging economies

China, India, and Brazil are expected to offer major growth opportunities for the hollow fiber filtration market players. China is estimated to be a high-growth market for bioprocessing products due to the country's growing government support and private investments. Companies in China are increasingly making biologics-related investments and hiring a skilled workforce for their operations. Also, R&D investments in markets such as India and Brazil have increased significantly over the last few years. Key players are establishing new facilities, R&D centers, and innovation centers in these emerging countries to capitalize on the available growth opportunities. For instance, in April 2021, Chime Biologics raised another USD 65 million to help build and kit out a second plant in Wuhan, China. The new plant will join Chime's first facility, built around a modular manufacturing system from Cytiva Life Sciences. Similarly, in January 2021, Lonza (Switzerland) opened its first manufacturing site for biologics in China. Lonza will combine Cytiva's KUBio modular facility and single-use equipment with supporting its Good Manufacturing Practice (GMP) manufacturing integrated with its platforms and expertise in development, including cell line construction and process development.

Despite the undermined global economy, the Indian pharmaceutical industry is experiencing unprecedented growth. The Indian government has laid out the Pharma Vision 2020 document for making India one of the leading destinations for drug discovery and innovation. The Indian biologics market is expected to reach USD 12 billion by 2025, at a CAGR of 22% from 2019 to 2025 (Source: IBEF). India has also become a leading destination for clinical trials, contract research, and manufacturing biologics and pharmaceutical drug products.

Thus, the growing biomanufacturing facility in these countries will provide lucrative growth opportunities for the market.

Challenge: Membrane fouling and fiber breakage

Irreversible fouling and fiber breakage are the main problems concerning hollow fiber filtration. Conductive membranes have the potential to mitigate fouling through the induction of Rayleigh-Bénard convection, gas evolution, electrochemical oxidation, or electrostatic repulsion of foulants. These membranes are usually prepared with conductive polymers and particles or a blend of conductive particles and a conventional polymer. The fouling can be assumed to be due to internal fouling by protein and/or external fouling by a residual.

Due to the flexibility of the fibers, these filters are more likely to break when under high strain compared to other filtration methods such as tubular or spiral-wound elements. Hollow fiber membranes tend to have moderate capital costs, but high operating costs compared to other configurations. High price and membrane fouling issues challenge the greater adoption of hollow fiber filters in biopharmaceutical filtration processes.

By material segment, the polymeric segment accounted for the largest share of the hollow fiber filtration industry in 2020.

Based on material, the hollow fiber filtration market is segmented into polymeric and ceramic filters. The polymeric segment is further sub segmented into polysulfide/polyethersulfone (PS/PES), polyvinylidene fluoride (PVDF), and other polymeric materials (cellulose & cellulose acetate, mixed cellulose ester, and polypropylene). In 2020, the polymeric segment accounted for the largest market share of the market. The large share of this segment is primarily attributed to the hydrophilic nature of PES/PS, low protein-binding properties, and its wide range of applications.

By application, the continuous cell perfusion segment accounted for the largest share of the hollow fiber filtration industry in 2020.

Based on application type, the hollow fiber filtration market is segmented into continuous cell perfusion, harvest and clarification, and concentration and diafiltration. In 2020, continuous cell perfusion accounted for the largest market share due to the advantages of hollow fibers in continuous cell perfusion, such as enabling efficient cell separation (with low shear) and allowing robust large-scale manufacturing.

By technique, the microfiltration segment accounted for the largest market share of the hollow fiber filtration industry in 2020.

Based on technique, the hollow fiber filtration market is segmented into microfiltration and ultrafiltration. In 2020, the microfiltration segment accounted for the largest share of the global market due to the availability of a wide range of pore sizes which have vast applications such as separation of a virus, bacteria, aerosols, and innumerable macromolecules from fluids, without the requirement of autoclaving a procedure.

By end users, the pharmaceutical and biotechnology manufacturers accounted for the largest market share of the hollow fiber filtration industry in 2020.

Based on end users, the hollow fiber filtration market is segmented into pharmaceutical and biotechnology manufacturers, contract research organizations (CROs) & contract manufacturing organizations (CMOs), and other end users. In 2020, the pharmaceutical and biotechnology manufacturers segment accounted for the largest share of the market. The large share of this segment is attributed to the increasing demand for hollow fiber filters in ultrafiltration, diafiltration, and microfiltration processes in biopharmaceutical manufacturing and the growing adoption of continuous manufacturing processes (due to advantages such as improved manufacturing process efficiency and flexibility).

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North America accounted for the largest share of the hollow fiber filtration industry in 2020.

North America accounted for the largest share of the hollow fiber filtration market in 2020. This region's large share can be attributed to North American companies focusing primarily on new products such as perfusion systems, the convenience and cost-efficiency of hollow fibre filters, and the rising demand for filtration systems for the biopharmaceuticals industry.

Prominent players in the hollow fiber filtration market are Repligen Corporation (US), Danaher (US), Asahi Kasei Corporation (Japan), Parker-Hannifin Corp (US), Sartorius Stedim Biotech S.A (France), TOYOBO CO., LTD (Japan), and Cantel Medical (US). The key players in this market are focusing on strategic expansions, and acquisition to expand their presence in the market.

Recent Developments of Hollow Fiber Filtration Industry:

• In 2020, Sartorius Stedim Biotech (France) acquired WaterSep BioSeparations to expand its product offerings in the market.
• In 2020, Repligen Corporation (US) acquired ARTeSYN Biosolutions. This acquisition helped expand the company’s offerings in the market.
• In 2020, Repligen Corporation (US) acquired Engineered Molding Technology. This acquisition expanded Repligen’s line of single-use filtration products and gave the company more flexibility to scale and expand its single-use systems portfolio in the market.
• In 2020 Danaher (US) acquired the Biopharma business from GE Company’s Life Sciences division. This business is known as Cytiva and acts as a standalone operating company within Danaher’s Life Sciences segment. This acquisition strengthened Danaher’s position in the market.