The demand for blockchain development services continues to accelerate across sectors. From finance to supply chain and gaming, multiple industries are actively adopting decentralized systems to unlock new capabilities and operational value. A growing number of enterprises and startups are seeking reliable blockchain development companies in USA to support this shift through advanced solutions and technical expertise. Below is a compiled list of ten leading firms offering custom blockchain development and enterprise-grade services in 2025.
1. Antier
Locations: USA, India, UK, Australia, UAE
Workforce: 700+ blockchain experts
Projects Delivered: 1000+ across DeFi, NFTs, and crypto platforms
Ranked among the top blockchain development companies in USA, Antier delivers full-cycle development services to support DeFi platforms, crypto tokens, NFT marketplaces, and more.
2. Unicsoft
Headquarters: USA
Certifications: Hedera, Tezos, Solana
Team Size: 800+ specialists
Unicsoft provides a wide range of blockchain development services, including NFT solutions, DePIN infrastructures, and tokenization systems. The company emphasizes speed, clarity, and real-world problem-solving through blockchain technology.
3. Eva Codes
Locations: USA, Ukraine, Portugal
Completed Projects: 150+
Ratings: Highly reviewed on Clutch
Eva Codes offers fast-track delivery of Web3 products such as dApps and back-end blockchain systems. Focused on early-stage companies, the team emphasizes agility and close project alignment.
4. MLG Blockchain
Locations: New York, Toronto
Tech Expertise: Ethereum, Bitcoin, Hyperledger, EOS, and more
MLG Blockchain brings a platform-agnostic approach to development, helping businesses choose and implement the most suitable tech stack for smart contracts, blockchain infrastructure, and enterprise solutions.
5. Interexy
Based in: USA
Team: 350+ blockchain professionals
Client Base: 300+ globally
Interexy delivers blockchain platforms across healthcare, logistics, and supply chain sectors. Focus areas include security compliance and end-to-end product development.
6. Peiko
Location: USA
Services: Custom blockchain application development
Peiko focuses on delivering modular blockchain applications tailored to core business challenges. Solutions are designed for both startups and established enterprises.
7. SpaceDev
Operations: USA, Uruguay, Argentina, Colombia
Specialization: Web3 games, MVP development
SpaceDev offers technical R&D and commercial-grade dApps, with a focus on quick go-to-market delivery. Projects often involve crypto integrations and multi-agent blockchain systems.
8. Dexola
Headquarters: USA
Projects: 40+ since 2017
Dexola works on DeFi systems, play-to-earn platforms, and blockchain-based tools. Known for strategic architecture and flexible development approaches.
9. Innovecs
Locations: USA, UK, Israel, Ukraine
Team: 200+ engineers
Innovecs builds blockchain platforms for finance, e-commerce, and digital identity. Use cases include KYC systems, enterprise wallets, and blockchain-based verification.
10. PixelPlex
Based in: USA
Experience: Over 17 years in the blockchain space
PixelPlex supports digital transformation through smart contracts, custom protocols, and full-scale blockchain architecture. Active across fintech, real estate, and cybersecurity.
Selecting the right blockchain development company depends on multiple factors such as technical expertise, industry experience, and the ability to deliver scalable solutions. The companies listed above continue to set high benchmarks in custom blockchain development and are well-positioned to lead future innovations across the decentralized economy.
